Remynd Nv

Katholieke Universiteit Leuven

Koen De Witte

Katrien Princen

Hasane Ratni

Mark Rogers-Evans

Gerard Griffioen

Bart De Taeye

Emilie Blanche

Matthias Heinrich Nettekoven

Johan Gerard Griffioen

Tom François L Van Dooren

The present provides compounds and methods for preventing and/or treating epilepsy and/or neurodegenerative disorders. More particularly, the invention provides inhibitors of PDE6δ for use in the prevention and/or treatment of neurodegenerative disorders and/or epilepsy.

Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders

The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R, R, R, L, L, L, L, Land n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders. 

Oxadiazole compounds

The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, Formula (I), wherein R, R, R, L, L, L, L, and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders. 

2,7-diazaspiro[3.5]nonane compounds

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Ukkel, Belgium

Koen De Witte