Merck + Co., Inc.

Rutgers, The State University of New Jersey

Bioresources International Inc.

Kodzo Gbewonyo

James E Simon

Michael G Sturr

Joseph Nti-Gyabaah

Mingfu Wang

Mohamed M Rafi

David J Pollard

Daniel Fahene Acquaye

Russell Fieldon Boyd

Kathleen A Telari

Yaw Asianowa

James Christopher McWilliams

The present invention provides methods for reducing the production of nitric oxide, inducible nitric oxide synthase protein and mRNA, and cyclooxygenase-2 protein and mRNA in cells both in vivo and in vitro via the administration of extracts and compounds derived from the seeds ofWarb. (), commonly known as African nutmeg. These extracts and compounds, namely,butter,butter acid extract, sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, are also useful in the treatment and prevention of a battery of adverse health conditions in human, animal, and avian subjects that are advanced by the production of nitric oxide or its metabolites and/or by the activity of cyclooxygenase-2. Methods for the isolation ofbutter acid extracts are also provided.

Antioxidant and anti-inflammatory activity of compounds and preparations from African nutmeg seeds

The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr; receptor antagonists.

Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates

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Somerset, NJ, United States of America

Kodzo Gbewonyo