Teva Pharmaceutical Industries Limited

Kobi Chen

Valerie Niddam-Hildesheim

Greta Sterimbaum

Evgeny Shapiro

Judith Aronhime

Claude Singer

Nina Finkelstein

Anita Liberman

Gideon Pilarsky

Santiago Ini

Natalia Shenkar

Anna Balanov

Yuriy Raizi

Ronit Yahalomi

Viviana Braude

Yaron Shmuely

Naama Chasid

The present invention relates to a process for preparing paliperidone from its intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one.

Process for the synthesis of 9-hydroxy risperidone (paliperidone)

The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.

Purification of montelukast

Provided are alkyl ammonium crystalline salts of rosuvastatin that provide for purification of rosuvastatin and its pharmaceutically acceptable salts.

Crystalline ammonium salts of rosuvastatin

The present invention provides a process comprising admixing a thioether with about 1.05 to about 1.6 molar equivalents of an active chlorine-containing oxidant, preferably sodium hypochlorite, and about 2.5 to about 5.0 molar equivalents of an alkali metal base; and recovering a sulfoxide that is preferably pantoprazole, lansoprazole, omeprazole, or rabeprazole. The process may further comprise contacting the sulfoxide with a source of sodium ions, preferably sodium hydroxide, to produce the sodium salt of the sulfoxide. The invention also relates to novel chlorinated derivatives of pantoprazole including 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chloromethyl]sulfinyl]-1H-benzimidazole and 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-chlorohydroxymethyl]sulfinyl]-1H-benzimidazole and processes for making them. The invention also relates to processes of quantifying and identifying a compound other than pantoprazole in a mixture of pantoprazole and at least one other compound.

Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole

The present invention provides a process for the preparation of the rosuvastatin intermediate FPP-CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.

Process for the preparation of rosuvstatin

The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.

Diastereomeric purification of rosuvastatin

The present invention provides processes for preparing montelukast.

Processes for preparing montelukast sodium

The present invention provides a process for the preparation of the rosuvastatin intermediate FPP&#x2014;CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.

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Ramat Hasharon, Israel

Kobi Chen