Shionogi Company Limited

Kobee Kobayashi

Takayasu Sonoyama

Bunji Kageyama

Hiroyoshi Tani

Shigeo Yagi

Masahiro Tanimoto

Tahiko Honjo

A novel reductase is produced from a microorganism which belongs to genus Corynebacterium and is useful as a catalyst which catalizes, in the presence of NADPH, reduction of 2, 5-diketo-D-gluconic acid or its salts to 2-keto-L-gulonate or the corresponding salts thereof. It also catalizes reduction of 5-keto-D-fructose to sorbose, in the presence of NADPH.

2,5-diketo-D-gluconic acid reductase

A provision of the disclosed grating composed of closed loops of plurality of parallelly-arranged straps with clearances between adjacent straps is made to encompass a space of a body of a revolution defined by a vane-type impeller. It proves to be effective for improving gas-absorption by a better gas-liquid contact in a chemical process or fermentation process.

Vane-type fluid impeller and method of aerating a liquid

2-Keto-L-gulonic acid is prepared from 2,5-diketo-D-gluconic acid through microbial conversion. The 2-keto-L-gulonic acid producing microorganism available for this microbial conversion includes strains which belong to the genus Corynebacterium. The incubation of the microorganism in a medium containing 2,5-diketo-D-gliconic acid as well as the direct contact of any products obtained from the microbial cells with a substrate containing said 2,5-diketo-D-gluconic acid may be used in the disclosed process.

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Takatsuki, Japan

Kobee Kobayashi