Tsinghua University

Ko-Wei Chang

Gwo-Bin Lee

An-Chung Chiang

Yen-Hung Chen

Shu-Chu Shiesh

Hsin-I Lin

Ching-Chu Wu

Yen-Chien Huang

The present invention provides a Hemoglobin A1c-specific aptamer and a Hemoglobin-specific aptamer. The aptamers were selected in vitro using SELEX and a microfluidic chip system. The aptamers established low free energy, thus were more stable than conventional antibodies. The high specificity of the aptamers to Hemoglobin A1c or Hemoglobin allows them to be effectively used in diagnosis of diabetes and/or anemia.

Hemoglobin A1c-specific aptamer, hemoglobin-specific aptamer, and applications thereof

A high-efficiency multiple-pass nonlinear wavelength converter and amplitude modulator employs a variable dispersion element between adjacent passes of a nonlinear wavelength conversion process in a single nonlinear optical material substrate. When controlled by a voltage via the electro-optic effect, the variable dispersion element dynamically alters the phase matching condition of the multiple-pass nonlinear wavelength conversion process and thus modulates the laser output amplitude. When the phase mismatch between passes is completely compensated by the variable dispersion element, the multiple-pass nonlinear wavelength converter achieves its maximum efficiency.

High-efficiency multiple-pass nonlinear optical wavelength converter with an electro-optic phase compensator and amplitude modulator

Growing community of inventors

Hsinchu, Taiwan

Ko-Wei Chang