Juridical Foundation the Chemo-Sero-Therapeutic Research Institute

Lsi Medience Corporation

Mitsubishi Chemical Medience Corporation

Ko Igami

Tomoko Ono

Fumio Furusaki

Shinichiro Watanabe

Tomoharu Okazaki

Koichi Shinmyozu

Koichi c/o Kimotsuki-Gun Medical Associated Hospital Shinmyozu

A method for detecting a condition in a patient with disturbance of consciousness, by analyzing an amount and/or activity of a von Willebrand factor-cleaving protease, and a kit for detecting a condition in a patient with disturbance of consciousness, comprising an antibody or a fragment thereof which specifically binds to a von Willebrand factor-cleaving protease, or a von Willebrand factor or a fragment thereof, are disclosed. Examples of the detection of a condition include a detection of cerebrovascular disease, a detection of arteriosclerotic vascular disease, and a detection or prediction of severity.

Method and kit for detecting condition in patient with disturbance of consciousness

A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura (TTP), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) and the amount of vWF in a patient that has been diagnosed with DIC is disclosed. Using the method of the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be made from among patients diagnosed with DIC, which could not previously be distinguished on the basis of only clinical findings or known markers. Also disclosed is a kit for determining an appropriate treatment option, the kit comprising an antibody or a fragment thereof which specifically binds to ADAMTS13.

Method for determining treatment of disseminated intravascular coagulation

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Tokyo, Japan

Ko Igami