Ge Healthcare Limited

Knut Richard Dyrstad

Torgrim Engell

Julian Grigg

Torild Wickstrom

Jonathan Robert Shales

Thanushan Rajanayagam

Ingvil Gausemel

Olav B Ryan

Kristine Romoren

Johanthan R Shales

The present invention provides a novel method for the preparation ofF-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.

Formulation and method of synthesis

The present invention provides a composition comprising anti-1-amino-3-F-fluorocyclobutyl-1-carboxylic acid (F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.

The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Method of operating an automated radiopharmaceutical synthesizer

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Oslo, Norway

Knut Richard Dyrstad