Princeton University

Knut Drescher

Bonnie L Bassler

Howard A Stone

Martin F Semmelhack

Colleen T O'Loughlin

Albert Siryaporn

Laura C Conrad-Miller

Yi Shen

Antivirulence strategies to combat, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the twoquorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

Molecules and compositions that inhibit gram negative bacteria and their uses

Methods and systems of measuring biofilms and/or biofilm streamers are presented. The system has at least one channel, a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, methods of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also presented. Uses of the system, methods and identified compounds are presented for medical and/or industrial environments.

Systems and methods to detect biofilm streamer growth and their uses

Growing community of inventors

Princeton, NJ, United States of America

Knut Drescher