Aktiebolaget Leo

Knut Bertil Hogberg

Hans Jacob Fex

Imre Konyves

Torsten Rune Perklev

Sten Gunnar Veige

Anders Robert Stamvik

B Goran Fredholm

New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R.sup.1 can be hydrogen, lower alkyl, halogen, or lower alkoxy, X can be oxygen, sulphur, or a monovalent carbon-to-carbon bond, A can be alkylene, aminoalkylene, or lower-alkanoyl aminoalkylene, and A together with X also can be a monovalent carbon-to-carbon bond, with a corticoid steroid.

Cortical steroid nitrogen mustard compositions and treatment therewith

Novel symmetrical secondary phosphoric acid esters having the general formula ##SPC1## Wherein the substituent R is positioned in meta or para position relative to the phosphoric acid ester group; processes for the preparation of said esters; and compositions containing said esters. The esters are i.a. useful as selective inhibitors of prostaglandins and compounds with prostaglandin activities. They also selectively antagonize the slow reacting substance (SRS).

Medicinal compositions and methods of use involving phosphoric acid

This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N.sup.4 halogenalkyl-N.sup.4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.

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Helsingborg, Sweden

Knut Bertil Hogberg