The United States of America, As Represented by the Secretary, Department of Health and Human Services

Irras Usa, Inc.

Kleanthis Xanthopoulos

Richard A Morgan

Christos Panotopoulos

Lance Boling

Jarmo Wahlfors

Tim Kovac

Timothy Kovac

A fluid exchange system may include a control unit comprising a processor; a tube set attachment removably connected to the control unit, the tube set attachment comprising a tube set fluidly connected to a fluid source and a drainage receptacle; a catheter fluidly connected to the tube set; and at least one sensor positioned on at least one of the control unit and the tube set attachment, wherein the control unit may be configured to supply fluid to a patient through the tube set and drain fluid from the patient via the tube set, and wherein the control unit may be configured to receive measurements from the at least one sensor to adjust the supply of the fluid to the patient and the drainage of the fluid from the patient.

Fluid exchange system and related methods

This invention provides a Togavirus-amplified retrovirus vector and a novel method for packaging a retrovirus cassette that contains a heterologous nucleic acid, which is amplified in a packaging cell cytoplasm by a Togavirus vector. The retroviral cassette is packaged into infectious retrovirus particles by retroviral packaging cells. These retroviral particles carrying the retroviral packaging cassette are then used to infect host cells.

Retroviral packaging cassettes amplified in the cytoplasm by autocatalytic Togavirus vectors

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La Jolla, CA, United States of America

Kleanthis Xanthopoulos