Kali-chemie Aktiengesellschaft

Klaus-Wolf Von Eickstedt

Horst Zeugner

Wolfgang Milkowski

Werner Stuhmer

Salah-Eldin Rahman

Wilhelm Kaupmann

N.sub.1 -[3-(4'-fluorobenzoyl)-propyl]-N.sub.2 -[2-(2'-chloro-5'-methylphenoxy)ethyl]-piperazine of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The compounds are sedatives of low toxicity.

N,[3-(4'-fluorobenzoyl)propyl]-N.sub.2 -(2'-chloro-5'-methylphenoxy)ethyl]p

Compounds which are amino carbonyl derivatives of benzofurans which have the formula ##STR1## in which R is a hydrogen, halogen, or alkyl radical containing up to 4 carbon atoms, X is a phenyl, halophenyl, alkylphenyl, or alkoxyphenyl radical, the alkyl moieties of which contain up to 4 carbon atoms, and Y is a dialkylamino radical, the alkyl moieties of which contain up to 4 carbon atoms, or a pyrrolidino, piperidino, hexamethylenimino, morpholino, piperazino, 4-methylpiperazino, or 4-(2-hydroxyethyl)piperazino radical, and acid addition salts thereof, processes for their preparation, and pharmaceutical compositions containing these compounds.

Amino carbonyl derivatives of benzofurans, processes for their

1,4-diazacycloalkane derivatives of the formula ##SPC1## Wherein R is hydrogen, halogen, lower alkoxy, nitro or lower secondary amine, R.sub.1 is lower alkoxyphenyl, nitrophenyl or trifluoromethylphenyl or wherein R.sub.1 is phenyl, that is disubstituted by two halogen, by two lower alkyl, by halogen and nitro, by halogen and lower alkyl, by halogen and lower alkoxy or by lower alkoxy and lower alkoyl, lower in these definitions meaning from 1 to 4 carbon atoms and wherein n, n' and m are 2 or 3; And pharmaceutically acceptable acid addition products of these compounds. The compounds are sedatives with an analgesic and anti-histaminic effect and possess a low toxicity.

N-[3-(p-f-benzoyl)-propyl]-N'-[2.(nitro,nitro-el, or methoxyphenyl)-ethyl]-

Piperazine derivatives having the following general formula ##EQU1## in which n is 2 or 3, X is an oxy or thio radical, and A and B are each a radical of the group consisting of phenyl radicals containing at most three substituents of the group consisting of nitro, trifluoromethyl, halogen, cyano, and alkyl, alkoxy, alkylthio, acyl, and alkylsulfonyl radicals containing at most 6 carbon atoms, and similar cycloalkyl and cycloalkylalkyl radicals, their acid addition salts, processes for their production, and pharmaceutical compositions containing the same. The compounds have a very favorable action on the central nervous system and are effective agents for the treatment of anxiety states, psychoses, emotional disturbances, aggressive tendencies, and can be used generally for the treatment of psychiatrically disturbed and psychoneurotic patients.

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Berlin, Germany

Klaus-Wolf Von Eickstedt