Solvay Pharmaceuticals, Gmbh

Abbott Products Gmbh

Klaus Witte

Dieter Ziegler

Reinhard Brueckner

Michael Weske

Yvan Fischer

Michael Mlinaric

Brian Moloney

Lester Marrison

Christiane Boecker

David Sykes

Matthias Straub

Paulus Antonius Remigius Koopman

Compounds corresponding to formula I, wherein R, R, R, R, R, R, R, R, R, Rand n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process. Furthermore, pharmaceutical compositions comprising the compounds of Formula I and related methods of treatment.

[object Object]

A combination therapy is disclosed for treating or inhibiting cardiovascular or metabolic diseases or conditions through a combination of at least one inhibitor of neutral endopeptidase (=NEP), at least one inhibitor of the endogenous endothelin producing system and at least one HMG CoA reductase inhibitor. Pharmaceutical compositions are also described comprising NEP inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors and the use of these pharmaceutical composition in the prophylaxis or treatment of cardiovascular and/or metabolic disorders or diseases in mammals (including humans).

Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors

The use of compounds corresponding to formula I: in which R, R, R, R, Rand Rhave the meanings given in the description for treating cardiac arrhythmias and other disease states.

Compounds corresponding to formula I: in which R, R, R, R, Rand Rhave the meanings given in the description; a process for the preparation of these compounds; intermediate products used to prepare such compounds, and pharmaceutical compositions containing such compounds.

Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them

Growing community of inventors

Hannover, Germany

Klaus Witte