Aventis Behring Gmbh

Behringwerke Aktiengeseschaft

Klaus Wellner

Norbert Heimburger

Gerhardt Kumpe

Karl-Heinz Wenz

Gerhard Kumpe

A process for the preparation of a concentrate of von Willebrand factor is described, entailing a solution of a complex of this factor with factor VIII:C being optionally pasteurized and treated with an anion exchanger, there being no binding of the von Willebrand factor.

Pasteurized, purified von Willebrand factor concentrate and a process for the preparation thereof

A process for the preparation of a pasteurized factor VIII concentrate with high specific activity and stability is described, which comprises adsorbing impurities from the solution containing the factor VIII by at least two-fold adsorption with Al(OH).sub.3, an anion exchanger or Ca.sub.3 (PO.sub.4).sub.2, preferably with two different adsorbents from this group.

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Marburg, Germany

Klaus Wellner