Miles Inc.

Bayer Aktiengesellschaft

Bayer Intellectual Property Gmbh

Klaus Wehling

Holger Heidenreich

Herbert Hugl

Jurgen Kocher

Karlheinz Hildenbrand

Piero Fossati

Gunther Beck

Gerhard Wolfrum

Nan-Horng Lin

Hermann Perrey

Bernhard Schulte

Robert P Hatch

Meinhard Rolf

Claus Burkhardt

Dittmar Nerger

Werner Kroll

Alexander Riebel

Aloysius Engel

Georg Frank

Scott Ruetten

Hans-Hagen Von Dohren

Dagmar Kubitza

Florin Seng

Son-Mi Park

Thomas Doege

Frank Misselwitz

Philip R Strom-Jensen

The present invention relates to the field of blood coagulation, more specifically it relates to a method of treating a thromboembolic disorder by administering once daily a direct factor Xa inhibitor in oral dosage form to a patient in need thereof, wherein the factor Xa inhibitor has a plasma concentration half life indicative of a bid or tid administration interval, e.g. of 10 hours or less.

Prevention and treatment of thromboembolic disorders

2-Thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Substituted 2-thiazolyl tetrazolium salt indicators

Phenyl substituted 2-thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Phenyl substituted 2-thiazolyl tetrazolium salt indicators

The present invention is directed to the use of polymer blend films consisting of polycarbonate and polyalkylene terephthalate supports for diagnostic test strips.

Use of polymer blend films as supports for diagnostic test strips

Naphthotriazolium salts which are chromogenic indicators for reducing substrate, such as NADH or NADPH.

Naphthotriazolium salts

General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

Analytical method using tetrazolium salt indicators having a reflectance

The present invention relates to a process for the production of porous, and particularly macroporous, membranes. The membranes produced by the process are highly absorbent and can therefore be employed, as supporting matrices for test strips. These test strips can be used for the detection of substances to be analyzed in a liquid.

Process for the production of porous membranes, the membranes produced

The present invention is related to compounds of the general formula (I) ##STR1## wherein R.sup.1 denotes hydrogen, halogen or C.sub.1 -C.sub.4 alkyl and

AS-triazine compounds

Indicator compounds, method of their preparation and use of those

Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators. The indicators of the invention contain compounds having the following general formula ##STR1##

Indicators for the detection of thiol groups

A method for detecting hydrogen peroxide wherein a sample is contacted with a peroxidase or a peroxidatively-active substance and a redox indicator of the following ##STR1## in which A and D independently of one another represent phenyl, pyridyl or imidazolyl,

Method for detecting hydrogen peroxide employing triaryl- and

2-Hydrazono-4,6-dinitrobenzthiazolones of the formula ##STR1## in which X.sub.1 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -hydroxyalkyl, C.sub.1 -C.sub.4 -sulphoalkyl or C.sub.1 -C.sub.4 -sulphatoalkyl, and

2-hydrazono-4,6-dinitrobenzthiazolones useful to form dyestuffs and as

The invention relates to new dicyanoethylaryl derivatives and to processes for their preparation. The compounds according to the invention can be used as redox indicators, such as, for example, for the detection of hydrogen peroxide with the aid of peroxidases or peroxidatively active substances. These redox indicators are futhermore suitable for the detection of peroxidases or peroxidatively active compounds, it also being possible to use other peroxides as oxidizing agents.

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Wuppertal, Germany

Klaus Wehling