Merz+co. Gmbh & Co.

Merz & Co.

Klaus W Hummel

Arthur Scherm

Dezsoe Peteri

Eberhard Amtmann

Gerhard Sauer

Wolfgang Schatton

Novel antitumor and antiviral xanthate compounds, a process for their production, pharmaceutical compositions containing said xanthate compounds, and a method of combating viruses and tumors therewith, are disclosed.

Xanthates as antitumor agents

The invention refers to antiviral and antitumor compositions which are useful for the control of viruses and tumors and which, in addition to a known antiviral or antitumor active xanthate, contain an adjuvant which increases its antiviral and antitumor action. The adjuvant is an ionic, preferably an anionic, compound with a lipophilic group and a hydrophilic group, preferably an alkali metal deoxycholate or a compound the lipophilic moiety of which is a straight or branched, saturated or unsaturated, aliphatic group with six to eighteen carbon atoms, and the hydrophilic group of which has one or two carboxyl, sulphate, sulphonate, or phosphate groups, or a pharmaceutically-acceptable salt thereof.

Antiviral and antitumor xanthate pharmaceutical compositions

N-oxides of pyridyl carboxylic acid esters of the following formula are described: ##STR1## wherein R is ##STR2## wherein X is a hydrogen atom, straight or branched C.sub.1 -C.sub.5 -alkyl, C.sub.5 -C.sub.12 -cycloalkyl, 1-adamantyl, or cyclohexylacetyl, and wherein Y is a hydrogen atom, straight or branched C.sub.1 -C.sub.5 -alkyl, 2-ethylbenzofuranoyl-3, C.sub.5 -C.sub.12 -cycloalkyl, or 2-[(4-chlorophenoxy)-2-methylpropanoyloxy]ethyl; a process for the manufacture thereof, pharmaceutical compositions containing these compounds, and method of using the same. These compounds are suited for use in the treatment of hyperlipidemas.

Pyridyl N-oxides

Novel antiviral xanthate compounds, a process for their production, pharmaceutical compositions containing said xanthate compounds, and a method of combating viruses therewith, are disclosed.

Xanthates and antiviral use thereof

Novel hypolipidemic nicotinates and related esters, being phenoxy organic compounds, are disclosed, as well as pharmaceutical compositions thereof and method of treating hyperlipidemia therewith.

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Frankfurt-am-Main, Germany

Klaus W Hummel