Baxter International Inc.

Baxter Healthcare Sa

Octapharma Ag

Baxalta Gmbh

Klaus Tschetschkowitsch

Kurt Schnecker

Nebojsa Nikolic

Michaela Frey

Wolfgang Grabmayer

Thomas Jancik

Matthias Fried

Barbara Riegler

Alma Kasapovic

Friedrich Scheiflinger

Michael Dockal

Hans Christian Hedrich

Andreas Goppelt

Georg Lattner

Almira Dugic

Caroline Covini

The present invention relates to a stable C1-esterase-inhibitor (C1-Inh) preparation, which is liquid or lyophilised, characterised by a histidine content of 5-400 mM but does not contain citrate or phosphate. It further relates to a kit including the C1-Inh preparation.

C1-esterase inhibitor preparation

The present invention provides a preparation comprising fibrinogen and a sulfated polysaccharide as a one component composition or as a kit of parts comprising fibrinogen and sulfated polysaccharide as separated components. The present invention further provides a fibrin clot like structure obtainable by a defined process, a hemostatic patch, a two-component syringe system and various uses of the described preparations, fibrin clot like structures and patches.

Preparations based on fibrinogen and sulfated polysaccharides

A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The method generally includes passing a liquid mixture containing a protein (e.g., an aqueous vWF mixture) through a filter while applying a counter pressure to the liquid mixture filtrate to accurately reduce and control the pressure differential across the filter. The disclosed method has the advantage that relatively high filtration flow rates can be achieved at relatively low pressure differentials, in contrast to high pressure differentials, which actually reduce the filtration flow rate of protein liquid mixtures. Further, the method can recover substantially all of the protein that is initially present in the liquid mixture.

Counter-pressure filtration of proteins

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Vienna, Austria

Klaus Tschetschkowitsch