Hoechst Schering Agrevo Gmbh

Klaus Trinks

Klaus Bartsch

Hans-Dieter Pohlenz

Rainer H&ouml;fgen

Roger Peeters

Bert Uijtewaal

Rob Dirks

The invention is directed to a process for the generation of male sterility in plants comprising the steps of (a) transforming a plant cell with DNA sequences that selectively inhibit the expression of essential metabolic compounds and (b) regenerating plants from said plant cells. Cells impaired in the biosynthesis of basic metabolic compounds undergo starvation and eventually die. Such pathways include amino acid biosynthesis, nucleic acid biosynthesis and other biosynthetic pathways such as citric acid cycle, pentose phosphate pathway, fatty acid metabolism, vitamin biosynthesis that will render the cell inactive due to nutrient depletion, if one or more enzymes or proteins involved in this pathway would become inactive by using inhibitory DNA constructs.

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Flörsheim, Germany

Klaus Trinks