University of Pennsylvania

Csl Behring Gmbh

Jüstus-Liebig-Universität Giessen

Klaus T Preissner

Douglas B Cines

Khalil Bdeir

Annette Feussner

Juergen Roemisch

Hans-Arnold Stoehr

Wiegand Lang

Gudrun Muth-Naumann

Malgorzata Wygrecka

Christian Kannemaier

Fumie Nakazawa

Triantafyllos Chavakis

Ewa Jablonska

Triantafylios Chavakis

The present invention provides methods for treating interstitial lung diseases, comprising administering to an individual an effective amount of an inhibitor of coagulation factor XII. The invention further provides uses and pharmaceutical kits for that treatment.

Factor XII inhibitors for treating interstitial lung disease

The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angiogenesis mediated by alpha-defensins.

Inhibition of angiogenesis by neutrophil alpha-defensins

A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said monoclonal antibody, and its proenzyme are described. A suitable monoclonal antibody is produced by hybridoma cell line DSM ACC 2533. The application of the inhibitory, monoclonal antibody in the stabilization of blood clotting preparations and in preparations for reducing the coagulability of the blood is disclosed.

Inhibitory monoclonal antibody against blood clotting factor VII-activating protease

The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angiogenesis.mediated by alpha-defensins.

Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins

Growing community of inventors

Glessen, Germany

Klaus T Preissner