Boehringer Ingelheim Gmbh

Boehringer Ingelheim Kg

Klaus Stockhaus

Herbert Merz

Adolf Langbein

Gerhard Walther

Herbert Koppe

Werner Kummer

Helmut Stahle

Wolfgang Hoefke

Helmut Wick

Wolfram Gaida

Matthias Grauert

Franz Esser

Franz J Kuhn

Walter Kobinger

Rolf Banholzer

Helmut Ensinger

Hans Michael Jennewein

Leon I Goldberg

Ingrid Wiedemann

Franz Josef Kohn

Wolfgang Abele

Gerard Walther

The present invention relates to 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for preparing them and their use as pharmaceutical compositions.

14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine,

The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compound as well as its salts are useful as analgesics.

N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof

Compounds of the formula ##STR1## wherein X, Y and Z are each independently hydrogen, halogen, lower alkyl, halo(lower alkyl), lower alkoxy, halo(lower alkoxy), (lower alkyl)thio or halo(lower alkyl)thio, or

Analgesic 1-acetonyl-2-(phenylimino)-imidazolidines and salts thereof

Compounds of the formula ##STR1## wherein R is bromine or trifluoromethyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs, analgesics and locomotion inhibitors.

Bradycardiac or analgesic

The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.

N-(2-methoxyethyl)-noroxymorphone and pharmaceutical compositions for

This invention relates to substituted imidazo[1,2-a]imidazoles and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.

Imidazo[1,2-a]imidazoles in the treatment of pain, hypertonia and

This invention relates to substituted imidazo[1,2-a]pyrimidines and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.

Substituted imidazo[1,2-a]pyrimidines and pharmaceutical compositions

Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl;

Analgesic 2-(2-alkoxy-ethyl)-2'-hydroxy-6,7-benzomorphans and salts

Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, and

Quaternary derivatives of noroxymorphone which relieve intestinal

Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl; and R.sub.2 is hydrogen, methyl or ethyl; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and morphine antagonists.

Analgesic and morphine antagonistic

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, hydroxyl, trifluoromethyl or cyano; and

2-[N-phenyl-N-(cycloalkyl-methyl)-amino]-2-imidazolines and salts thereof

Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.

N-Tetrahydrofurfuryl-noroxymorphones, their salts, and analgesic

Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,

Analgesically useful 2-tetrahydrofurfuryl-5-lower

Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.

Pharmaceutical compositions containing an

Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,

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Ingelheim am Rhein, Germany

Klaus Stockhaus