Warner-Lambert Company

Goedecke Aktiengesellschaft

Godecke Aktiengesellschaft

Goedecke Gmbh

Cu Chemie Uetikon Gmbh

Klaus Steiner

Hubert G Barth

Simon Schneider

Wolfgang Dieter Herrmann

Manfred Westermayer

Ulrike Wolfsperger

Ulrich Bayer

Jurgen Kleinschroth

Hans-J&uuml;rgen Betche

Jean-Marie Grunenwald

Stefan Gangkofner

Hans-Jürgen Betche

Charles S Combs

Gunter Crone

Hans-Joachim Witzke

The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula Iby reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of further catalysts at room temperature.

Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate

Method for arylating aza-heterocycles with activated aromatic compounds in the presence of caesium carbonate

Method for producing symmetrical and asymmetrical carbonates

METHOD FOR THE SIMPLIFIED PRODUCTION OF (3-CHLORO-4-FLUOROPHENYL)-&lsqb;7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4-YL&rsqb;-AMINE OR (3-CHLORO-4-FLUOROPHENYL)-&lsqb;7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL&rsqb;-AMINE

The invention relates to a method of producing heterocyclic carbamates of the general formula (I) by reacting aza-heterocyclic compounds with alkyl- or aryl-halides in the presence of carbon dioxide and alkali carbonate, and to new compounds of the general formula (I).

Method of producing heterocylic carbamates from aza-heterocyclic compounds and carbon dioxide

Racemic separation of ketamine

The present invention provides a process for the preparation of tricyclo- [3.3.1.1.sup.3,7 ]dec-2-yl-[R-(R*,R*)]-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diph enyl-10-oxa-2,5,8-triazaundecanate, an important compound in the preparation of a new class of cholecystokinin inhibitors, wherein N-[(benzyloxy)carbonyl]-(R)-.beta.-amino-1-azido-2-phenylethane is hydrogenated, and subsequently, by means of carbon dioxide, the resulting N.sup..beta. -[(benzyloxy)-carbonyl]-(R)-.beta.-amino-2-phenylethylamine carbonate is precipitated out. This is coupled by the carbodiimide process with N-[(2-adamantyloxy)-carbonyl]-.alpha.-methyl-R-tryptophane.

Process for the preparation of tricyclo-[3.3.1.1.sup.3,7

Processes for the preparation of cyclic amino acid derivatives useful in the treatment of cerebral diseases such as epilepsy are disclosed. Novel intermediates useful in processes are also disclosed.

Process for the preparation of cyclic amino acids and intermediates

The present invention concerns the fumaric acid salts of 1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl) 1,6-naphthyridine-3-carboxylic acid [2-(N-methyl-N-phenylmethylamino)ethyl]ester, processes for preparing them, and pharmaceutical compositions containing them. Methods of using the compounds for treating high blood pressure and diseases of heart and blood vessels.

Certain derivatives of

The present invention provides a process for the separation of the naphthyridine derivatives (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid ethyl ester and (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid [2-(N-methyl-N-phenylmethylamino)ethyl] ester into the optical antipodes by use of the (.+-.)-1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluoromethylphenyl)-1,6-n aphthyridine-3-carboxylic acid benzyl ester and optically-active O,O'-dibenzoyltartaric acid. Said optical antipodes are calcium antagonists useful in the treatment of blood vessel diseases.

Production of optical isomers of certain 1,6-naphthyridine-3-carboxylate

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Emmendingen, Germany

Klaus Steiner