Lts Lohmann Therapie-systeme Ag

Lts Lohmann Therapie-systeme Gmbh

Lts Lohman Therapie-systeme Gmbh & Co. Kg

Klaus Schumann

Peter Steinborn

Reinhold Meconi

Michael Horstmann

Thomas Hille

Bodo Asmussen

Christoph Schmitz

Wolfgang Laux

Frank Seibertz

Mohammad Sameti

Ronald Hackbarth

Horst Dzekan

Hans-Rainer Hoffmann

Walter Muller

Christian Von Falkenhausen

Karin Ludwig

Karsten Cremer

Ludwig Grader

Frank Theobald

Markus Bee

Tina Rademacher

Bernd Grünes

Dieter Anh&auml;user

Torsten Grunenberg

Uwe Bungarten

Rolf Böhm

Anna Schlüter

Provided is a method for producing a sealed-edge pouch with a laminate composite stored therein. In some non-limiting embodiments or aspects the laminate composite is detached from a laminate composite web having a carrier film with substrates which are arranged thereon and are covered by means of a respective cover film. An intermediate body is supplied to the laminate composite web or to the laminate composite or is moulded into the carrier film such that the intermediate body or the intermediate bodies surrounds/surround all of the free surfaces of the substrate at least in regions. The laminate composite and all of the intermediate bodies are introduced between two packaging material webs. The packaging material webs are sealed to each other. Finally, the sealed-edge pouches are separated. A device for producing sealed-edge pouches and a sealed-edge pouch produced according to this method are also provided.

Device and method for producing

The present invention is directed to transdermal therapeutic systems that are free of fibrous constituents, as well methods for producing such transdermal therapeutic systems. A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system. Exemplary printing methods include application methods based upon a distributor plate of an application device.

Fibre-free transdermal therapeutic system and method for its production

The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

System for the transdermal delivery of active ingredient

A transdermal therapeutic system which is free of fibrous constituents, and a method for the production of such a transdermal therapeutic system A preparation containing active substance is applied by a printing method onto the pressure-sensitive adhesive layer of the transdermal therapeutic system.

A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile

A process for dispensing pressure-sensitive adhesive laminates () or laminate sections from a movable primary () onto a movable secondary carrier band (), the laminates (), upon deflection of the primary band () around a dispenser edge (), being detached and dispensed onto the secondary band (), is characterized in that the primary band () is provided with at least one separation line or predetermined breaking line, thus subdividing it into at least two strips ('), and that the strips are individually drawn from separate sections () of the dispenser edge ().

Method and device for dispensing adhesive laminate segments

The invention relates to a process for producing hot-seal packs, in particular for transdermal therapeutic systems, by welding to one another, at predetermined linear regions and at polymer layers facing towards one another, two laps of continuous pack material composed of two or more layers. To this end, one (or two) sealing tool(s) are used to bring the pack material into contact with pressure and heat. To improve the quality of the welded seams without altering the cycle rate, according to the invention the sealing time is doubled and the temperature of the sealing tool(s) ( ) is reduced so that there is a considerable reduction in the temperature reached within the pack material ( ), this temperature then being only slightly above the melting point of the polymer used. An example of a sealing tool ( ) is given (FIG. ).

Method for producing heat bonded packages and tool for implementing said method

The invention relates to a composite laminate, especially a transdermal therapeutic system (TTS) that contains in at least one layer a component that is sensitive to moisture. Said system further comprises one layer that is spatially separate from said at least one moisture-sensitive layer and that is capable of absorbing moisture. The spatial separation can be achieved by means of a horizontal or vertical separation layer.

Composite laminate and method for its production

A primary packaging unit for film-like or wafer-like administration forms for oral application with an off-cut of an upper web of packaging material and of an lower web of packaging material is characterized in that a plurality of dosage units of a film-like or wafer-like administration form, individually sealed in flat compartments formed without cold or hot forming of the packaging material and spaced at a distance to one another, are present in a primary packaging unit, and there are perforations between the compartments which enable the separation of individual compartments, if necessary.

Primary packaging unit for film-like or oblate-like administered shapes

The invention relates to a method for dispensing flat forms, such as labels, stickers, transdermal therapeutic systems, flat medicaments for oral application, etc, in a controlled manner. According to said method, the outer contour of the flat form ( ) is punched out from a strip-shaped starting material and connecting bridges ( ) hold the flat form ( ) and the edge of the punched layer together. These connecting bridges ( ) break when the flat forms are dispensed via a deflector edge ( ). The inventive method can be advantageously used for packing individual flat forms in primary packaging. The invention also relates to a specialised punching device used in the method.

Method and device for dispensing flat forms

Process for the production, transport and storage of a therapeutic system which is in the form of a plaster and has an active layer supersaturated with active ingredient and containing the active ingredient in homogeneous dispersion or in solution, characterized in that it is carried out avoiding process parameters which favour or induce crystallization of active ingredient, and any type of pressure operating on the plaster and, in particular, on the active layer is avoided while it is carried out.

Method for producing a therapeutic system in the form of plaster

The present invention relates to a process and a device for the production of a flat administration form comprising a preparation that contains pharmaceutical active substances. The flowable preparation is conveyed to an applicator unit (,) by means of a metering pump, and flows through a distribution chamber (,) having a distribution plate (,) provided with passages (,). This application device (,) transfers the preparation onto a layer of the flat administration form (,) which is therefor contacted with the distribution plate (,) for a short time.

Growing community of inventors

Neuwied, Germany

Klaus Schumann