Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Sanofi-a Ventis Deutschland Gmbh

Sanofi-aventis Pharma Gmbh

Klaus Scholich

Gerd Geisslinger

Martin Michaelis

Michael John Parnham

Irmgard Tegeder

Christian Brenneis

Marco Sisignano

Sebastian Zinn

Susanne Schiffmann

Stephan Hohmann

Natasja De Bruin

The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (CIPNP). The invention provides antagonists cytochrome P450 epoxygenases (CYP), and more specifically antagonists of CYP2J2, as therapeutics for use in the treatment of neuropathic pain such as CIPNP. CYP2J2 antagonists were identified to alleviate CIPNP in-vivo, and therefore are provided additionally in combination with chemotherapeutics for the treatment of diseases such as cancer or other proliferative disorders. The CYP2J2 antagonists reduce chemotherapeutic induced pain and therefore allow for a higher dosing of the chemotherapeutic during cancer treatment. In addition the invention relates to the use of CYP2J2 agonists, or metabolites of CYP2J2, for sensitizing TRPV1. In this context the invention proposes to use combinations of CYP2J2 agonist or metabolites and transient receptor potential vanilloid 1 (TRPV1) agonists to treat disorders that respond to TRPV1 agonists, such as neuropathic pain.

CYP2J2 antagonists in the treatment of pain

Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds.

Method for alleviating pain using sphingosine-1-phosphate and related compounds, and assays for identifying such compounds

The present invention relates to a method for the prophylaxis or treatment of pain using compounds of formula I, in which R, R2, R3, R4 and R5 have the meanings indicated in the specification.

2-amino-1,3-propanediol compounds for the treatment of acute pain

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Dreieich, Germany

Klaus Scholich