Somanta Limited

Klaus Pors

Laurence Patterson

Paul Henry Teesdale-Spittle

Anthraquinone compounds of the general formula (I) or a salt thereof (Formula I) in which Rto Rare each selected from the group consisting of H, Calkyl, X, &#x2014;NHRN (R)in which Ris a Calkanediyl and each Ris H or optionally substituted Calkyl, and a group of formula (II) in which at least one of R, Rand Ris selected from X, and Xsubstituted Calkyl and any others are H or Calkyl; Ris selected from H, Calkyl, Xand Xsubstituted Calkyl; m is 0 or 1; n is 1 or 2; Xis a halogen atom, a hydroxyl group, a Calkoxyl group, an aryloxy group or an acyloxy group; and Xis a halogen atom, a hydroxyl group, a Calkoxyl group, an aryloxy group or an acyloxy group; provided that at least one of Rto Ris a group of formula (II). The N-oxides are useful prodrugs which are selectively bioreduced in hypoxic tumours to the corresponding cyclic amine derivatives. The amine compounds are cytotoxic and may be used as alkylating agents having topoisomerase II inhibiting activities in cancer therapy. 

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West Yorkshire, United Kingdom

Klaus Pors