Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Bayer Cropscience Ag

Bayer Intellectual Property Gmbh

Bayer Cropscience Nv

Jähn, Peter

Klaus Ochmann

Michael Harnau

Franco Fois

Mike Küster

Nils Burkhardt

Bernd Kalthof

Georg Schmidt

Linn Schneider

Kerstin Ilg

Peter Jähn

Andreas Schade

Karl-Hermann Koeching

Piet Soetaert

Ingmar Dorn

Edgar Diessel

Bastian Budde

Michael Habig

Barthel Bach-zelewski

Angelika Köllen

Johannes Linzbach

Martin Leube

Edgar Dieβel

The invention relates to an automated system and a method for determining the effect of active ingredients on organisms such as insects, Acariformes and nematodes in an assay plate containing wells with the aid of image-acquisition and image-analysis technology. The invention allows the characterization of the population of the organisms at multiple time points.

System for determining the effect of active ingredients on acariformes, insects and other organisms in an assay plate containing wells

A dispensing device includes a housing having at least one pressure chamber, having a supply opening for the supply of liquid into the pressure chamber and having a multiplicity of conduits between the pressure chamber and an external side of the housing, there being situated in each of the conduits a tube, the first end of which protrudes into the pressure chamber and the second end of which protrudes out of the housing on the external side.

Metering device

A method and a system for rapid kinetic fluorescence measurement in high-throughput screening with high time-resolution includes providing a microtiter plate having a transparent base and multiple assay wells, a dispensing system arranged above the microtiter plate for simultaneously adding liquid into multiple assay wells, an illumination system beneath the microtiter plate for illuminating the multiple assay wells simultaneously through the transparent base, a detection system for detecting electromagnetic radiation from the multiple assay wells simultaneously through the transparent base, adding 0.3-300 &#x3bc;l of liquid per assay well from the dispensing system into the multiple assay wells, illuminating the multiple assay wells simultaneously through the transparent base using the illumination system before or from the time point of the start of the addition, detecting the electromagnetic radiation from the multiple assay wells simultaneously at a time interval of 1-1000 ms between individual measurement points.

Method and system for taking measurements in a high-throughput screening with high time resolution

The invention relates to a device () and a method for determining the action of active ingredients on nematodes and other organisms in aqueous tests. The device () according to the invention comprises a holder () for a cell culture plate () having multiple wells () in which the nematodes can be filled with the active ingredients, said cell culture plate () having a bottom side (), a top side () and also side walls extending between bottom side () and top side (), a camera () which is used to record images of preferably the bottom side () of the cell culture plate (), a lighting mechanism () having at least a first light source () which illuminates the cell culture plate (), there being arranged between the first light source () and a first side wall () of the cell culture plate () in the installed state a first optical unit which directs the light of the first light source () through the first side wall () in the direction of the bottom side () of the cell culture plate (). The method according to the invention makes it possible to simultaneously investigate many active ingredients within a very short time.

Device and method for determining the action of active ingredients on nematodes and other organisms in aqueous tests

Methods, kits and compositions of matter are provided which allow amplification of nucleic acid or interest or DNA of interest, comprising the steps of isolating template nucleic acid or DNA from a biological sample using an alkaline extraction solution and directly adding the extract to a reaction mixture, under conditions to amplify the nucleic acids, wherein the isolated template nucleic acid or DNA in the alkaline extraction solution is not diluted or not neutralized prior to the addition to the reaction mixture.

Methods, compositions and devices for amplification of nucleic acids

The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses using the apparatus. The apparatus comprises: a plurality of subsystems for each performing different operations on microtiter plates; a transporting subsystem for automated movement of microtiter plates in three directions X, Y and Z in order to transport plates from one subsystem to another subsystem within the apparatus; a liquid handler comprising at least two liquid handling probes, wherein said liquid handler is integrated in the transporting subsystem; an insertion/removal subsystem for inserting, removing and storing microtiter plates and equipment for sampling and dilution operations, wherein said insertion/removal subsystem is mechanically operated, without the need for electrical components implemented in that subsystem.

Apparatus for automatically performing analyses

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Leverkusen, Germany

Klaus Ochmann