Roche Diagnostics Gmbh

Roche Molecular Systems, Inc.

Klaus M&uuml;hlegger

Herbert Von Der Eltz

Frank Seela

Hans-Georg Batz

Zigmunt Kasimierczuk

Helmet Rosemeyer

Werner Bourgeois

Heinz-Peter Muth

Klaus Kaiser

2&prime;-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.

2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis

The invention concerns compounds of the general formula (I) in which i:he residues R to R have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DNA polymerases and can thus be incorporated into RNA or DNA oligonucleotides and are especially suitable for labelling and detecting nucleic acids or for DNA sequencing.

Heterocyclic compounds and their use for isolating nucleic acids

The invention concerns pyrrolo-&lsqb;3,2-d&rsqb;pyrimidine, pyrazolo-&lsqb;4,3-d&rsqb;pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V

C-nucleoside derivatives and their use in the detection of nucleic acids

The present invention provides desazapurine-nucleoside derivatives of the general formula:

Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents

Growing community of inventors

Polling, Germany

Klaus Mühlegger

Growing community of inventors

Polling, Germany

Klaus M&uuml;hlegger

Klaus Mühlegger