Bayer Aktiengesellschaft

Klaus Luttermann

Uwe Claussen

Edgar Diessel

Ludger Heiliger

Aziz El Sayed

Aziz E Sayed

Walter Weichel

Winfried Kosch

Arno Becker

Peter Orth

Reinhard Riess

Markus Weidauer

The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled with a fluorescent dye are mixed with the molecule library which is in the form of a suspension. The mixture is plated out on a two-dimensional substrate ( ) after the excess, unbound ligands have been washed out. Then the local fluorescence intensities on the substrate are electro-optically identified in a fluorescence microscope ( ) and electronically discriminated in accordance with given selection criteria. The objects selected and localised in this way are then sequentially positioned exactly by a displacement, the coordinates of which are controlled by the image calculator, between the substrate ( ) and a separation actuator ( ) and are spatially separated from the substrate ( ) by the separation actuator ( ).

Process and device for the screening of molecules with regard to their individual binding behaviour towards at least one given ligand

The device serves for the transfer of microobjects, in particular of biological objects, from a current substrate ( ) to a target substrate. In this case, use is made of a displaceable pipette system which is connected to a pressure generating device for aspirating in and flushing out the biological objects. The pipette system is disposed in a micromanipulator ( ) and consists mainly of a substantially vertically disposed microcapillary ( ) having a clear width of 1 &mgr;m to 50 &mgr;m.

Device for separating micro objects

A method of identifying different plastics, wherein each plastic is provided with a plurality of fluorescent dyes which differ in terms of their emission frequencies and/or in terms of the duration of their fluorescence, so that a fluorescence pattern, which is distinguished by the duration of the fluorescence and/or by the frequencies occurring, can unambiguously be assigned to each plastic.

Method for the identification of plastics

Process for rendering a plastic identifiable by adding 5 to 10,000 ppb of a fluorescent marker to the plastic during or after is manufacture.

Process for identifying plastics by addition of fluorescent dye

Growing community of inventors

Lohmar, Germany

Klaus Luttermann