Rohm Gmbh

Rohm Gmbh Chemische Fabrik

Roehm Gmbh Chemische Fabrik

Bpsi Holdings, Inc.

Roehm Gmbh Chemical Factory

Evonik Rohm Gmbh

Klaus Lehmann

Dieter Dreher

Hans-Ulrich Petereit

Dieter Kraemer

Werner Siol

Hubert Rauch

Joachim Knebel

Hermann Plainer

Manfred Assmus

Harry Goetz

Horst Pennewiss

Werner Hoess

Wolfgang Klesse

Kurt H Bauer

Gerhard Markert

Thomas P Farrell

George Reyes

Dev K Mehra

Karl-Dieter Voelger

Theodor Mager

Thomas Sufke

Roland Hartl

Roland Schweder

Colin Liddiard

Christian Rietzel

Charles F Vesey

Wolfgang Weisbrod

Herbert J Kramer

Rdiger Jelitte

Wolfgang Kleese

Giuseppe Di Pascale

Ottilie E Kehr-Dreher

Ramireddy Chittamuru

Hermann Osterwald

A non-toxic, edible, enteric film coating, dry powder composition for use in making an aqueous enteric suspension which may be used in coating pharmaceutical tablets comprises a) an acrylic resin, said resin comprising i) from 20 to 85 percent by weight of at least one alkyl acrylate or alkyl methacrylate moiety, ii) from 80 to 15 percent by weight of at least one vinyl or vinylidene moiety having a carboxylic acid group capable of salt formation, and iii) from 0 to 30 percent by weight of at least one other vinyl or vinylidene moiety copolymerizable with i) and ii), b) an alkalizing agent capable of reacting with the acrylic resin such that, after reaction, 0.1 to 10 mole percent of the acidic groups in 1a-ii) are present in the salt form, and c) a detackifier.

Acrylic enteric coating compositions

A time-release laminar pharmaceutical composition, comprised of rolled or folded layers of a polymer film, that contain a pharmaceutically active substance, in which the outer surface area of the polymer film which contains the active substance, and which is accessible to the digestive juices, amounts to at most 25% of the entire surface area in the rolled or folded state, and the rolled or folded layers adhere to one another in such a way that the laminar form of medication maintains its rolled or folded form for a period of at least one hour in the release test according to USP 23, Method A, apparatus 2, at 37&deg; C. and 50 rpm, in artificial gastric juice, and at least 30% of the active substance contained in it is released in the rolled or folded state.

Time-release laminar pharmaceutical composition

A dermal therapeutic system which exhibits a prolonged release of a drug comprising at least one pharmaceutical agent combined with poly(meth)acrylates in the form of at least one layer of the therapeutic system, the poly(meth)acrylates being a mixture, which is produced from a melt, comprising (1) at least one (meth)acrylic polymer containing functional groups and (2) at least one (meth)acrylic polymer which regulates the flow behavior of the poly(meth)acrylate mixture and which contains no functional groups or only insignificant amounts of functional groups.

Dermal therapeutic system made of a meltable poly (meth) acrylate

Thermoplastic materials which comprise a copolymer of

Thermoplastic material for drug coatings which dissolve in intestinal

Coatings and binders for pharmaceutical forms containing a copolymerizate, wherein the copolymerizate is made up of:

Coating and binder for pharmaceutical agents

Coating agents comprising a liquid phase, a polysaccharide decomposable in the colon, such as locust bean gum or guar gum, and a film forming polymer preferably having hydrophilic groups, which agent, when used for the coating of oral dosage unit forms, give coatings of high mechanical strength which are first decomposed under the influence of glycosidic enzymes in the colon; oral dosage unit forms incorporating such agents.

Oral dosage unit form

What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.

Method for making carrier systems for biologically active materials

A water insoluble lipophilic emulsifier having a hydrophile-lipophile balance (HLB) of 3.5 to 7, added to an aqueous dispersion containing a polymer comprising acrylic acid, methacrylic acid, their alkyl esters, and/or their alkylaminoalkyl esters, acts as a lubricant and parting agent when the resulting mixture is used for coating pharmaceutical dosage forms and prevents the pharmaceutical dosage forms being coated from sticking to one another and to the walls of the coating apparatus used.

Aqueous film coating agent for solid medicaments

A conversion product of polysuccinimide useful as coating material for medicinal preparations and foodstuffs having the structure: ##STR1## wherein A is hydrogen or a straight or branched alkyl or alkylene group of 1 to 8 carbon atoms, optionally substituted by cycloaliphatic or aromatic groups, wherein the cyclic substituent can also contain heteroatoms, or by R--O--, ##STR2## or R.sub.3 R.sub.4 N groups, wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are hydrogen or branched alkyl or cycloalkyl groups each of which may contain oxygen and nitrogen atoms in the chain or in the ring of 1 to 10 carbon atoms;

Polymers derived from polysuccinimide, used as surface coatings for

A method of manufacturing polysuccinimides with molecular weights in the range 100,000 to about 200,000 by polycondensation of aspartic acid, with phosphoric acids as condensation agents, in at least two process stages, at temperatures of 100.degree.-250.degree. C. and under reduced pressure, where in the second stage the mixture containing aspartic acid and phosphoric acid undergoes subsequent condensation following comminution.

Method of increasing the molecular weight in the manufacture of

A method for obtaining redispersible powders of a copolymer having a dynamic glass transition temperature, T.sub.max, below 150.degree. C., by spray drying an aqueous dispersion thereof having a minimum film forming temperature, MFT, using an inlet temperature T.sub.i and an outlet temperature T.sub.o such that MFT&lt;T.sub.i &lt;T.sub.max and MFT&lt;T.sub.o &lt;65.degree. C.

Method for making redispersible synthetic resin powders

Aqueous dispersions of a water-swellable but water-insoluble polymer formed between a quaternary ammonium monomer and a nonionic monomer; methods for making such dispersions by dispersing said copolymers, in the form of a powder, in water; methods for coating pharmaceutical cores, powders, or granules with such dispersions; and coated pharmaceutical products made by such methods.

Aqueous coating dispersions

Pharmaceutical preparations having diuretic activity and comprising a peptide of the formula ##STR1## wherein (a) R.sub.1 and R.sub.2 are hydrogen and R.sub.3 is --OH, or ##STR2## or Y, or wherein (b) R.sub.1 is hydrogen, R.sub.2 is CH.sub.2 OH or ##STR3## and R.sub.3 is --OH or Y, or wherein (c) R.sub.1 is --CH.sub.2 OH and R.sub.2 is hydrogen or ##STR4## and R.sub.3 is --OH or Y, or wherein (d) R.sub.1 is ##STR5## R.sub.2 is hydrogen or --CH.sub.2 OH and R.sub.3 is --OH, --NHCH.sub.2 COOH, or Y, and

Pharmaceutical preparations having diuretic activity

A method for coating solid pharmaceutical formulations, comprising coating said solid formulation with an aqueous fluid, film forming coating medium comprising a dissolved polymer prepared from acrylic and/or methacrylic monomers having a side group containing a tertiary amine substituent, wherein the amine nitrogen atom is converted to the ammonium salt form; and then drying said coated film.

Method for coating pharmaceutical formulations

Coated pharmaceutical dosage forms which are resistant to gastric juice and release their active ingredient rapidly at a predetermined pH value in the range from pH 5 to pH 8 are obtained in accordance with the invention by coating pharmaceutical dosage forms with an aqueous dispersion containing dispersed latex particles of a first polymer which contains carboxyl groups and is water soluble between pH 5 and pH 8 and of a second water insoluble film forming polymer, in a weight ratio between 60:40 and 5:95.

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Rossdorf, Germany

Klaus Lehmann