Biolitec Pharma Marketing Ltd

Westfalische Wilhelms-universität Münster

Universität Paderborn

Biolitec Research Gmbh

Biolitec Holding Gmbh & Co Kg

Klaus Langer

Arno Wiehe

Volker Albrecht

Susanna Gräfe

Hagen Von Briesen

Wolfgang Birnbaum

Beate Röder

Gerhard Dieter Wieland

Annegret Preuss

Laura Mahlert

Dennis Mulac

Jingjiang Sun

Sylvia Wagner

Juliane Anderski

Matthias Wacker

Karin Löw

Dirk Kuckling

Thomas Knobloch

The present invention generally relates to the formation, chemistry and application of biologically active compositions. More particularly, the present invention relates to certain dyes, specifically porphyrin and chlorin derivatives, in combination with inventive polymers, i.e. light-cleavable polymers, that can be used as photosensitizer compositions for a wide range of light irradiation treatments such as photodynamic therapy of cancer, infections and other diseases. The dye derivatives may either be adsorbed on, or incorporated in, or attached to specific polymers, which as well form part of the invention.

Polymer-particle light-cleavable carrier systems for photodynamic therapy

Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.

Nanoparticle carrier systems based on human serum albumin for photodynamic therapy

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Münster, Germany

Klaus Langer