Boehringer Mannheim Gmbh

Klaus Koch

Wolfgang Schaumann

Fritz Kaiser

Wolfgang Voigtlander

Wolfgang Kampe

Kurt Stach

Felix Helmut Schmidt

Harald Stork

Edgar Hoyer

Cardioactive cardenolide-bis-digitoxosides of the formula ##STR1## in which R.sub.1 is a hydrogen atom, a hydroxyl group or an acyloxy radical containing up to 3 carbon atoms, and

Cardenolide-bis-digitoxoside alkyl compounds, pharmaceutical

The present invention provides 12-dehydrodigoxin oximes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms, lower acyl radicals or lower alkyl radicals or R.sub.1 and R.sub.2 together can represent an alkylidene radical containing 2 to 6 carbon atoms and R.sub.3 is a hydrogen atom or a lower alkyl or aralkyl radical. The present invention also provides a process for the preparation of these oximes and pharmaceutical compositions containing them and is also concerned with the use of these oximes for the preparation of pharmaceuticals for the treatment of cardiac insufficiency.

Cardioactive 12-dehydrodigoxin-oximes

New heterocyclic-substituted nebularin compounds of the formula: ##SPC1## Wherein

Heterocyclic-substituted nebularin compounds

Growing community of inventors

Mannheim, Germany

Klaus Koch