Genentech, Inc.

F. Hoffmann-la Roche Ag

Klaus Hoeflich

Lori Friedman

Deepak Sampath

Marcia Belvin

Mallika Singh

Jeffrey Wallin

Ulka Vijapurkar

Leisa Johnson

Sonal Patel

Mark Merchant

The invention provides a combination of a) a compound of Formula Ia: [insert Formula Ia], or a pharmaceutically acceptable salt thereof, and b) vemurafenib or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic treatment of a hyperproliferative disorder, such as cancer. 

Combinations of AKT inhibitor compounds and vemurafenib, and methods of use

Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 

Combinations of phosphoinositide 3-kinase inhibitor compounds chemotherapeutic agents, and methods of use

Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

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South San Francisco, CA, United States of America

Klaus Hoeflich