Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

G. Lufft Mess- Und Regeltechnik Gmbh

Klaus Hirzel

Michael Gerg

Lars Hillringhaus

Hans-Peter Josel

Johann Karl

Thomas Meier

Julia Riedlinger

Bernhard Eckert

Marcus-Rene Lisy

Dieter Heindl

Christoph Seidel

Michael Schraeml

Martin Kaufmann

Caroline Dorothea Hojer

Erasmus Huber

Leopold Von Proff

Edgar Voss

Magdelena Swiatek-de-Lange

Florian Huber

Magdelena Swiatek-de Lange

The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

Biotin-specific monoclonal antibody and use thereof

The present disclosure relates to specific binding agents binding to different PIVKA-II forms as compared to antibodies known so far in the art. The present disclosure also relates to methods of using the specific binding agents to detect the presence of PIVKA-II.

Binding agent and assay for PIVKA

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Baierbrunn, Germany

Klaus Hirzel