Novartis Ag

Irm LLC

Novartis Pharma Gmbh

Klaus Hinterding

Rudolf Duthaler

Gebhard Thoma

Gerhard Zenke

Nigel Graham Cooke

Anette Von Matt

Rolf Baenteli

Peter Nussbaumer

Peter Buehlmayer

Klemens Högenauer

Christos Papageorgiou

Rainer Albert

Claus Ehrhardt

Peter Ettmayer

Maurice Van Eis

Ichiro Umemura

Carsten Spanka

Naoko Matsuura

Osamu Ohmori

Frédéric Zecri

Kazuhiko Nonomura

Marie Claude Bernhard

Toshiyuki Honda

Louis Walliser

Nathanael Schiander Gray

Shifeng Pan

Lawrence Blas Perez

Yuan Mi

Sylvain Cottens

Wenqi Gao

Nathanael S Gray

Wei Wang

Volker Brinkmann

Sophie Lefebvre

Eva Erika Prieschl-Strassmayr

Wenqui Gao

Federic Zecri

Fan Yi

Kenneth Richad La Montagne

Thomas Baumruker

Kenneth Richard La Montagne

Nigel Cooke

Marie Bernhard

Ying Fan

There are provided compounds of formula I wherein X, R, R, R, R, R, R, R, Rand Rare as indicated in claim 1 , useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.

2,4-diaminopyrimidine derivatives

Disclosed are pyrimidine derivatives of formula wherein R, R, Rto R, and Z have a signification as indicated in claim, which have interesting pharmaceutical properties.

2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors

There are provided compounds of formula I wherein X, R, R, R, R, R, R, R, Rand Rare as indicated in claim, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.

A compound of formula (I) wherein R, R, R, Rand Rare as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them. 

Amino-propanol derivatives

Compounds of formula I, wherein X, a, b, R, R, R, Rand Rare as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.

Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

The present invention relates to new amino acid derivatives, process for the production, their use, in particular in transplantation, and pharmaceutical compositions containing them.

Amino acid derivatives

The present invention relates to amino-propanol derivatives, process for their production, their uses in treating and/or preventing diseases or disorders mediated by lymphocyte interactions, and pharmaceutical compositions containing them. For example, Compounds of formula I wherein A, R, R, R, Rand Rare as defined in the specification are described.

Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator

Disclosed are pyrimidine derivatives of formula wherein R, R, Rto R, and Z have a signification as indicated in claimwhich have interesting pharmaceutical properties.

2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors

Compounds of formula (I) wherein R, R, R, R, R, R, R, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.

Compounds of formula I wherein R, R, R, Rand Rare as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.

Compounds of formula I wherein m, R, Rand Rto Rare as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive properties.

2-amino-propanol derivatives

The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: wherein the substituents have the values mentioned herein.

Bis-aromatic alkanols

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Wittlingen, Germany

Klaus Hinterding