Eyesense Ag

Qiagen Lake Constance Gmbh

Ese, Inc.

Ese Embedded System Engineering Gmbh

Klaus Haberstroh

Achim Müller

Peter Herbrechtsmeier

Roman Gruler

Konrad Faulstich

Roland Schmieder

Achim Mueller

The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescence standards are corundum, fluorite, turquoise, amber, zircon, zoisite, iolite or cordierite, spinel, topaz, calcium fluorite, sphalerite or zincblende, calcite or calcspar, apatite, scheelite or calcium tungstate, willemite, feldspars, sodalite, a uranium mineral, a mineral containing Al, and in particular ruby and sapphire.

Fluorescence standard, and the use thereof

A sample holder, such as a microscope slide, is provided in the form of a card-shaped substrate or plate, preferably for use in an analytical reader. The sample holder comprises at least one hole, preferably a plurality of holes, for receiving a sample to be analyzed. The at least one hole extends completely through the substrate and is sized such that the sample is held within the at least one hole by means of the surface tension of the sample against the force of gravity. Optionally the substrate comprises a first upper substrate and a second lower substrate that together embed a porous membrane. As a further option the sample holder comprises a first cover attached to the top side of the first upper substrate and/or a second cover attached to the bottom side of the second lower substrate. Moreover a method for using such a sample holder in an analytical reader is provided, comprising the steps of: filling the at least one hole of the sample holder with a sample and reagent mixture; inserting the sample holder in the analytical reader; and analyzing the sample and reagent mixture in the at least one hole of the sample holder with the analytical reader.

Sample holder and method of using the same

The invention proposes a manual measuring appliance () and an analytical measuring system () which can be used to measure at least one analyte in an eye fluid of an eye (). The handheld measuring appliance () comprises a measuring system () and a positioning system (). The measuring system () can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor () in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system () is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye () and the handheld measuring appliance () and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (), wherein the calibration system () is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.

Device for measuring an analyte in an eye fluid

The invention proposes a manual measuring appliance () and an analytical measuring system () which can be used to measure at least one analyte in an eye fluid of an eye (). The handheld measuring appliance () comprises a measuring system () and a positioning system (). The measuring system () can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor () in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system () is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye () and the handheld measuring appliance () and also furthermore at least one further positioning co-ordinate. The positioning system () comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.

Apparatus for measuring an analyte in an eye fluid

Analytical sample detection device

The present invention relates to a hand-held fluorescence photometer and method for measuring an analyte level, preferably a blood glucose level, from an ocular fluid. The photometer is based on a dual beams measuring system and it is capable of defining the correct positioning for the measurement. Only when the apparatus is correctly positioned the actual analyte measurement automatically takes place.

Apparatus for measuring an analyte concentration from an ocular fluid

A device for the simultaneous detection of radiation of different wavelength, comprising a number of base modules arranged one on top of the other, an optical module and an electronic module. One device each for reflecting and/or deflecting radiation of a determined wavelength-range is provided in the base modules. The light-detecting elements are associated with one of the devices each. The invention also relates to a base module, a charging unit, a method for adjusting the device and to the use of the device.

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Bodman-Ludwigshafen, Germany

Klaus Haberstroh