Behringwerke Aktiengesellschaft

Dade Behring Marburg Gmbh

Behring Diagnostics Gmbh

Hoechst Aktiengesellschaft

Klaus Habenstein

Helmut Kohl

Hans-Erwin Pauly

Dieter Zopf

Winfried Bursch

Jurgen Romisch

Heinz-Jurgen Friesen

Joseph Stark

Gerd Grenner

Eckhard Schuler

Jurgen Lindner

Heinz-J&uuml;rgen Friesen

Joseph Stärk

Heinz-Jürgen Friesen

Joseph St&auml;rk

A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.

Sheet-like diagnostic device

The invention relates to a method for determining the ionic strength and/or the specific weight of aqueous liquids and a reagent for this purpose, the composition of the reagent being such that the color change indicating the ionic strength is essentially directly dependent on the specific weight of the liquid to be determined and not on a pH shift.

Reagent for determining the ionic strength and/or the specific weight of

The invention relates to a sampling kit for obtaining, in a rapid and gentle manner, a defined volume of lacrimal fluid for the purpose of reproducibly determining components of the lacrimal fluid.

Method for reproducibly determining the components of lacrimal fluid

Reagent for determining the ionic strength and/or the specific weight of aqueous liquids and a reagent for this purpose, the composition of the reagent being such that the color change indicating the ionic strength is essentially directly dependent on the specific weight of the liquid to be determined and not on a pH shift.

The present invention relates to reagents and processes for the preparation of diagnostics which use a chromogenic redox detection system and whose chromogenic redox detection system essentially remains unaffected by interference from reducing. compounds in the sample material.

Decreased interference redox detection system

The invention relates to fluorogenic compounds for the detection of hydrolyzing enzymes and the use of the fluorogenic compounds.

Fluorogenic compounds and their use

The present invention relates to reagents and processes for the preparation of diagnostics which use a chromogenic redox detection system and whose chromogenic redox detection system essentially remains unaffected by interference from reducing compounds in the sample material.

Decreased interference redox detection device

Chromogenic substrates for the detection of hydrolyzing enzymes, processes for the preparation of these chromogenic substrates and the use of the chromogenic substrates. The quantification of hydrolyzing enzymes for diagnostic purposes has to date been carried out by determination of the amounts of a fluorescent or highly absorbent chromogenic dyestuff liberated in the hydrolytic reaction, detection of which has in part been possible exlusively by instruments or in the neutral to alkaline pH range. After enzymatic hydrolysis, the chromogenic substrates according to the invention lead to highly sensitive and specifically measurable signals regardless of the pH range. Azo dyestuff compounds with the general formula

Azo dye chromogenic substrates

What are disclosed are polysaccharide derivatives of the formula ##STR1## in which n denotes a number from 100 to 12,500 and R denotes hydrogen, a carboxyalkyl or hydroxyalkyl group with 1 to 5 carbon atoms in the alkyl radical or a detectable molecular group, any combination of the (3n+2) R radicals being possible, but at least one R being a carboxyalkyl or hydroxyalkyl group and at least one R being a detectable molecular group, and a process for their preparation and their use for the determination of endohydrolases, in indicator paper and for the detection of metabolites in biological liquids, are described.

Method for determining the presence of endohydrolase in a liquid and

What are disclosed are a method for detecting substances having a peroxidative effect using a substituted or condensed pyridine, and a diagnostic agent containing a pyridine of this kind.

Substituted or condensed pyridines in a process for the detection of

Rapid diagnostic agent comprising an absorbent carrier matrix, a chromogen, a hydroperoxide, a detergent, an activator and a compound of the formula I ##STR1## or a copolymer containing such a compound, and, if appropriate, another protective colloid. A diagnostic agent of this type can be used in a method for detecting, in body fluids and excreta, peroxidatively active substances.

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Wetter, Germany

Klaus Habenstein