Bayer Aktiengesellschaft

Klaus Grohe

Karl G Metzger

Hans-Joachim Zeiler

Uwe Petersen

Michael Schriewer

Rainer Endermann

Thomas Schenke

Ingo Haller

Andreas Krebs

Klaus-Dieter Bremm

Erich Klauke

Karl-Georg Metzger

Paul-Ernst Frohberger

Volker Paul

Robert Frank Lammens

Wilhelm Brandes

Karl-Heinz Kuck

Hermann Hagemann

Hans-Joachim Scholl

Ernst Kysela

Franz Kunisch

Arnold Paessens

Herbert Voege

Thomas Philipps

Stephan Bartel

Wolfgang Dummer

Kai Rossen

Klaus Lurssen

Fritz Maurer

Dieter Arlt

Thomas Himmler

Engelbert Kuhle

Wilfried Schrock

Dieter Habich

Martin Scheer

Gerd Fengler

Klaus G Stunkel

Arundev H Naik

Volker Klimetzek

Gerhard Schluter

The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

Intermediates for

The invention relates to novel 1,6-naphthyridonecarboxylic acid derivatives, to processes for their preparation, to antibacterial compositions and feed additives in which they are present, and to novel intermediates for the preparation of these active compounds.

1,6-naphthyridonecarboxylic acid derivatives

2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,

2, 4, 5-trihalogeno- and 2, 3, 4, 5-tetrahalogenobenzene derivatives

Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##

Preparation of 7-(3-amino- and

##STR1## in which Z represents a residue of the structure ##STR2## A represents N or C--R.sup.5. The end products are antibacterially active.

Preparation of 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen, X.sup.2 is hydrogen, halogen, amino or other radical, R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical, R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.

7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic acid

The invention relates to novel derivatives of quinolone-carboxylic acid and naphthyridonecarboxylic acid which are substituted in the 7 position by a 1- (or 5-)amino-methyl-2- (or 3-)oxa-7-aza-bicyclo[3.3.0]oct-7-yl residue, their salts, processes for their preparation and antibacterial agents containing these compounds.

7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)quinolonecarboxylic and

The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

7-amino-1-cyclopropyl-6,8-dihalogeno-

2,4,5-Trihalogenobenzene derivatives of the formula ##STR1## is which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,

2,4,5-trihalogeno-and 2,3,4,5-tetrahalogenobenzene derivatives

2,4,5-trihalogeno- and 2,3,4,5-tetrahalogenobenzene derivatives

The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.

Quinolonecarboxylic acids

The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.

8-vinyl- and 9-ethinyl-quinolone-carboxylic acids

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partly hydrogenated isoindolinyl ring, processes for their preparation and antibacterial agents and feed additives containing these compounds.

7-isoindolinyl-quinolone-carboxylic acid derivatives

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and feed additives containing them.

Quinolone- and naphthyridonecarboxylic acid derivatives

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Odenthal, Germany

Klaus Grohe