Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Bayer Pharma Aktiengesellschaft

Lead Discovery Center Gmbh

Klaus Godl

Wilfried Schwab

Zoltán Greff

Bert Klebl

Axel Choidas

Edmund Hoppe

Doris Hafenbradl

Gerhard Müller

Don Simpson

Jackie Macritchie

Joelle Le

Henrik Daub

Jose Bravo

John Harris

Birgit Zech

Vladimir Savic

Andrea Missio

Brad Sherborne

Thomas Herget

Achim Freisleben

Christian Hartung

Peter Habenberger

Beatrice Felber

Ola Engkvist

Matt Cotten

Alexander Backes

Christoph Weber

Andreas Tebbe

Kirti Sharma

Michaela Bairlein

This invention relates to methods for the evaluation and/or quantification of the binding affinity of small molecules or other compounds to target components contained within an analyte, such as target proteins contained within the proteome of a cell or tissue.

Proteome-wide quantification of small molecule binding to cellular target proteins

The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases

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Krailling, Germany

Klaus Godl