Boehringer Ingelheim International Gmbh

Viratherapeutics Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Klaus Erb

Matthias Grauert

Christoph Hoenke

Matthias Hoffmann

Alexander Pautsch

Michael Paul Pieper

Stefan Scheuerer

Steffen Breitfelder

Trixi Brandl

Ingo Pragst

Udo Maier

Anne T Joergensen

Guido Wollmann

Philipp Mueller

Patrik Erlmann

John Edward Park

Tobias Friederike Nolden

The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Recombinant rhabdovirus encoding for CCL21

The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Recombinant rhabdovirus encoding for a CD80 extracellular domain Fc-fusion protein

The present invention relates to compounds of general formula (I), wherein the groups A, R, R, Rand Rhave the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-quinazolines and the use thereof as pharmaceutical compositions.

Thiazolyl-dihydro-quinazolines

Disclosed are thiazolyl-dihydro-quinazolines of general formula (I) wherein the groups Rto Rhave the meanings given in the claims and specification, the isomers thereof, and processes for preparing these compounds and their use as pharmaceutical compositions.

Thiazolyl-dihydro-quinazoline compounds and processes for preparing same

Thiazolyl-dihydro-quinazoline

Disclosed are compounds of general formula (I), wherein the groups R, R, Rand Rhave the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers and the mixtures thereof, and optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof, and processes for preparing these thiazolyl-dihydro-cyclopentapyrazoles and the use thereof as pharmaceutical compositions.

Thiazolyl-dihydro-cyclopentapyrazole

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Mittelbiberach, Germany

Klaus Erb