Leland Stanford Junior University

Klaus Dornmair

Harden M McConnell

Processes for increasing antigen binding capacity of a major histocompatibility complex (MHC) molecule or a chain thereof are described. Such processes comprise treating an antigen-bound MHC molecule or a chain thereof with an effective amount of an unfolding agent to release undesired antigen from the MHC molecule or chain and then treating the antigen-free MHC molecule or chain with an effective amount of a refolding agent to produce a functional MHC molecule or chain. Additionally, compositions of MHC molecules that are substantially free of undesired antigens or that have been bound with desired specific antigens, alone or in combination with pharmaceutically acceptable carriers and/or cytotoxic agents, are described. The present invention has utility for therapeutic administrations, drug screening, and diagnostics.

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Palo Alto, CA, United States of America

Klaus Dornmair