Basf Aktiengesellschaft

Basf Se Corporation

Abbott Laboratories Corporation

Evolva Sa

Basfaktiengesellschaft

Basf Akteingesellschaft

Klaus Ditrich

Karl-Otto Westphalen

Gerhard Hamprecht

Bruno Wuerzer

Helmut Walter

Matthias Gerber

Norbert Meyer

Volker Maywald

Wolfgang Siegel

Elisabeth Heistracher

Eberhard Ammermann

Gisela Lorenz

Albrecht Harreus

Oskar Zelder

Thomas Kuekenhoehner

Michael Breuer

Ralf Klintz

Wolfgang Ladner

Holger Hartmann

Birgit Hoff

Andrea Molt

Siegfried Strathmann

Johann-Peter Melder

Karl Eicken

Oliver Wagner

Michael Puhl

Hansgeorg Ernst

Michael Bartsch

Horst Mayer

Friedhelm Balkenhohl

Wolfgang Freund

Klaus Fischer

Klaus Henrich

Hartwig Schroeder

Christoph-Sweder Von Dem Bussche-Hunnefeld

Harald Winsel

Christoph N&uuml;bling

Jakob Weber

Christian Dully

Hubert Sauter

Wassilios Grammenos

Thomas Grote

Joachim Rheinheimer

Markus Gewehr

Peter Plath

Bernhard Hauer

Reinhard Stierl

Hartwig Schröder

Peter Schäfer

Andreas Gypser

Karsten Koerber

Bernd Müller

Jordi Tormo I Blasco

Stefan Haefner

Frank Schieweck

Alwin Rehfinger

Alois Kindler

Heinz Hillen

Ingo Rose

Andreas Keller

Peter Sch&auml;fer

Kai-Uwe Baldenius

Wolfgang Krause

Hartmann Konig

John-Bryan Speakman

Frank Wetterich

Thomas Saupe

Frank Haese

Ralf Boehling

Oliver Cullmann

Melanie Weingarten

Ralf Böhling

Hartmut Laatsch

Rudolf Karl

Michael Naesby

Markus Frede

Hans-Jurgen Weyer

Rene Backes

Bryan Cooper

Stefan Hergenr&ouml;der

Hartmann K&ouml;nig

Nina Schneider

Markus Schwab

Thomas Mueller

Peter Munster

Christophe Folly

Curt Aimé Friis Nielsen

Melanie Bonnekessel

Olaf Kutzki

Ulrich Block

Marta Zajaczkowski-Fischer

Johann-Christian Zechel

Andrea Piatesi

Christoph-Sweder Von Dem Bussche-H&uuml;nnefeld

Anaelle Hatsch

Pepa Dimitrova

Achim Weitze

Claus Otto Markert

Peter M&uuml;nster

Peter M Unster

The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2&#x2032;-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C-C-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base.  In the formulae (I) and (II), the variables are each defined as follows:

Method for preparing 2'-O-fucosyllactose

A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.

Process for preparing sebacic acid

Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Genes and processes for the production of clavine-type alkaloids

The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

Gene cluster for biosynthesis of cornexistin and hydroxycornexistin

The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

The present invention relates to a process for separating an enantiomer mixture of (R)- and (S)-3-amino-1-butanol optionally protected on the oxygen atom, and to a process for preparing essentially enantiomerically pure (R)-3-amino-1-butanol which optionally bears a protecting group on the oxygen atom.

Separation of an enantiomer mixture of (R)- and (S)-3-amino-1-butanol

The present invention relates to a process for the biocatalytic, enantioselective production of a &#x3b2;-amino acid precursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a &#x3b2;-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a &#x3b2;-amino acid precursor or a &#x3b2;-amino acid, and a method for obtaining said hydantoinase.

Preparation of beta-amino acids

The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.

Preparation of isomerically pure substituted cyclohexanols

The invention relates to a process for the preparation of (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent work-up.

Process for the preparation of (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine

A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.

Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid methyl ester sulfate by lipase acylation of racemic 4-(1-aminoethyl) benzoic acid methyl ester and sulfuric acid precipitation

The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R).

Method for producing optically active aminoalkylphenols

A process for preparing optically active trans-2,6-dimethylmorpholine by (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid, (ii) removing the salt formed from D-mandelic acid and one enantiomer of trans-2,6-dimethylmorpholine from the other enantiomer of trans-2,6-dimethylmorpholine and (iii) isolating the desired optically active trans-2,6-dimethylmorpholine.

Racemic separation of 2,6-trans-dimethymorpholine

A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described.

Preparation of optically active amines

Method for producing optically active amines

A 7-(R)-Aminotriazolopyrimidines of formula Iwhere the substituents and index are as defined below:

7-(r)-aminotriazolopyrimidines, the production thereof and use of the same for combatting phytopathogenic fungi

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Gönnheim, Germany

Klaus Ditrich