Cytos Biotechnology Ag

Klaus Dietmeier

Martin F Bachmann

Wolfgang Andreas Renner

Patrik Maurer

Alain Tissot

Paul Pumpens

Indulis Cielens

Regina Renhofa

Vania Manolova

Monika Bauer

Sebastian Fuchs

Conrad Coester

Nicole Schmitz

Yu Zou

Stephan Utzinger

The application is related to compositions and methods for the treatment of hypersensitivity, wherein the compositions comprise a particle packaged with immunostimulatory nucleic acids. The compositions of the invention are particularly useful in the treatment of atopic eczema, asthma and IgE-mediated allergy (type I allergy), especially pollen allergy and house dust allergy.

Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

CAT allergen conjugates and uses thereof

Growing community of inventors

Zurich, Switzerland

Klaus Dietmeier