Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Klaus-Dieter Willim

Klaus Rudolf

Henri Doods

Wolfgang Eberlein

Wolfhard Engel

Wolfgang Wienen

Michael Entzeroth

Heike-Andrea Wieland

Horst Dollinger

Franz Esser

Gerd Schnorrenberg

Gerhard Mihm

Jurgen Krause

Heike Andrea Wieland

NPY-antagonistic compounds of the formula ##STR1## Exemplary are: (A) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -bis(4-hydroxyphenyl)acetyl]-argininamide-trifluoracetate;

Amino acid derivatives, pharmaceutical compositions containing these

Amino acid derivatives, medicaments containing said compounds and

Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R,S)-N.sup.2 -(diphenylacetyl)-N-�(4-hydroxyphenyl)methyl!-N.sup.5 -(1H-imidazol-2-yl)-ornithinamide.

Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-argininamide-acetate.

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Hochdorf, Germany

Klaus-Dieter Willim