Veb Arzneimittelwerk Dresden

Klaus-Dieter Volzke

Klaus Braun

Werner Grawert

Rudolf Schirutschke

Detlev Groger

Monika Muller

Christoph Dauth

Liselotte Hohne

Klaus Breuel

Eva Borowski

Gisela Nordmann

Dieter Erge

Edda Knothe

Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts.

Process for the fermentation production of ergoline derivatives

Growing community of inventors

Dresden, undefined

Klaus-Dieter Volzke