Veb Arzneimittelwerk Dresden

Klaus Braun

Eva Borowski

Monika Muller

Klaus Breuel

Gisela Nordmann

Rudolf Schirutschke

Klaus Femmer

Edda Knothe

Rolf Ertel

Klaus-Dieter Volzke

Dieter Erge

Werner Grawert

Liselotte Hohne

Werner Forster

Gunther Gabsch

Christoph Dauth

Detlev Groger

Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts.

Process for the fermentation production of ergoline derivatives

Novel 21-deoxydihydroajmaline derivatives having the formula ##SPC1## Wherein R and R' are each the same alkyl group of 2 to 4 carbon atoms or R and R' together with the N atom with which they are associated form a saturated 5- or 6- atom ring, the atoms other than the nitrogen atom of which are all carbon atoms or one oxygen atom and the rest carbon atoms and X is the anion of a physiologically inorganic or organic acid, characterized by their antiarhythmic activity.

21-Deoxydihydroajmaline derivatives

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Klaus Braun