G.l. Pharma Gmbh

Klaus Bleymaier

Wolfgang Kroutil

Georg Gübitz

Georg Guebitz

Katrin Greimel

Martin Brandauer

Daniela Huber

Doris Lechner

Christof Wachter

Harald Wagner

Heimo Winkler

Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.

Abuse-deterrent pharmaceutical composition

Disclosed are pharmaceutical compositions comprising oxycodone and an oxycodone-processing enzyme, wherein oxycodone is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on oxycodone.

Abuse-deterrent pharmaceutical compositions

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Vienna, Austria

Klaus Bleymaier