Boehringer Ingelheim Kg

Boehringer Ingelheim Pharma Kg

Karl Thomae Gmbh

Klaus Binder

Norbert Hauel

Henning Priepke

Uwe Joerg Ries

Gerhard Mihm

Rainer Zimmermann

Armin Heckel

Wolfgang Wienen

Jean Marie Stassen

Rainer Zimmerman

Wolfgang Grell

Robert Sauter

Rainer Soyka

Thomas Mueller

Jean-Marie Stassen

Manfred Psiorz

Eric Haaksma

Wolfgang Weinen

Antithrombotic phenylalkyl derivatives of the formula

Antithrombotic phenylalkyl derivatives

Novel disubstituted bicyclic heterocycles, of which the following are exemplary:

Disubstituted bicyclic heterocycles, the preparation thereof and their

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula ##STR1## wherein R.sub.a to R.sub.c, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein R.sub.c denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein R.sub.c denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.

Bicyclic heterocycles, the preparation thereof, and their use as

The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which have valuable pharmacological properties, particularly the effect of extending the thrombin time, a thrombin inhibiting effect and an inhibiting effect on related serine proteases such as trypsin, pharmaceutical compositions containing this compound and processes for the preparation thereof.

Benzimidazolyl derivatives, pharmaceutical compositions containing these

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Wiesbaden, Germany

Klaus Binder