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Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Wired Connectons LLC

Deutsches Resourcenzentrum Fur Genomforschung Gmbh

Klaus Bienert

Ingo Truppel

Heiko Kraack

Andreas Vente

Volkhard Seiffert

Gerd Ihlenfeld

Rolf Zettl

A phase controller device according to the invention comprises a hardware core that is formed by a signal detector, a voltage-controlled oscillator, a phase comparator, and an integration unit, where the hardware core, by controlling the working clock pulse frequency of the microcontroller, brings an output clock pulse signal that is generated by a microcontroller into phase with the input clock pulse information that is received from the input data stream, and does so in such a manner that the jitter is low. The microcontroller executes a program with this working clock pulse, where with that program the microcontroller generates the output clock pulse signal with an output clock pulse frequency that is in a predetermined division ratio to the control clock pulse frequency that is generated by the voltage-controlled oscillator and is given to the microcontroller as a working clock pulse frequency. In this way the program enables the phase controller device according to the invention to process, with a microcontroller, external periodic signals, data, or events, where the software processes taking place in the microcontroller are always locked in phase with the periodic occurrence of these external signals, data, or events.

Device and method for phase synchronization with the aid of a microcontroller

The phase controller device according to the invention comprises a hardware core that is formed by a signal detector, a voltage-controlled oscillator, a phase comparator, and an integration unit, where the hardware core, by controlling the working clock pulse frequency of the microcontroller, brings an output clock pulse signal that is generated by a microcontroller into phase with the input clock pulse information that is received from the input data stream, and does so in such a manner that the jitter is low. The microcontroller executes a program with this working clock pulse, where with that program the microcontroller generates the output clock pulse signal with an output clock pulse frequency that is in a predetermined division ratio to the control clock pulse frequency that is generated by the voltage-controlled oscillator and is given to the microcontroller as a working clock pulse frequency. In this way the program enables the phase controller device according to the invention to process, with a microcontroller, external periodic signals, data, or events, where the software processes taking place in the microcontroller are always locked in phase with the periodic occurrence of these external signals, data, or events.

A freely traversable metering head with numerous metering devices, wherein the metering devices are each provided individually or block-by-block with an activating device, and wherein a controller traversable with the metering head is designed for the independent operation of one or more activating devices. Metering devices for such a metering head and procedures for their use are also disclosed.

Metering head for parallel processing of a plurality of fluid samples

The invention relates to a method for transferring, for instance, a biological material arranged in a given pattern, whereby the biological material is brought into contact with needles placed on the head of a robot and the biological material is transferred to a support, whereby the needles are hard metal needles fitted with a biocompatible coating. The biocompatible coating preferably consists of metal-nitrogen compounds. Preferably, an anticorrosion coating is applied underneath the biocompatible coating. Once the biological material has been arranged in a given pattern, the needles mounted on the robot head are arranged according to the same pattern. Preferably, the pattern corresponds to the pattern of the arrangement of microtitre plate wells. The invention also relates to a robot head fitted with the inventive hard metal needles. Said robot head particularly forms part of a picking and/or a spotting robot. The invention further relates to the utilization of hard metal needles fitted with a biocompatible coating for transferring, for instance, biological material arranged in a given pattern to a support.

Method for transferring biological material

An apparatus for determining the percentages of individual components of a mixture having at least two components of different electrical conductivities, the apparatus having at least two sensors connectable across an a.c. voltage source, and being arranged such that the mixture being introducible therebetween, wherein each sensor has a pin electrode having a first sensing surface for electrical contact with the mixture, and a plate electrode having a second sensing surface electrically insulated from the mixture, wherein the area of the second sensing surface is larger than the area of the first sensing surface; the pin electrode and the plate electrode of each sensor are each connected to the same potential of the voltage source.

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Gross Kreutz, Germany

Klaus Bienert