Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Kgaa

Klaus Beschmann

Steffen Neuenfeld

Andrew Barber

Inge Stein

Ulrich Fechtel

J&ouml;ran Stoldt

Holger Krummradt

Frank-Hardi Wartenberg

Horst Diekmann

Holger Beeres

Bernd M&uuml;ller

Wolfgang Heinz

The invention relates to a method for removing phosphoric acid, thiamine triphosphate and higher thiamine phosphates from solutions that contain phosphoric acid, thiamine monophosphate, thiamine diphosphate, diamine triphosphate and higher phosphates. The inventive method is characterized by passing the phosphoric acid solution of thiamine phosphates over a non-ionogenic adsorber resin which comprises unsaturated cyclic nitrogen bases and eluting thiamine monophosphate and thiamine diphosphate with a suitable solvent.

Method of purifying thiamine phosphates

The invention relates to a method for producing L-ascorbic acid from 2-keto-L-gulonic acid or 2,3-4,6-diacetone-2-keto-L-gulonic acid. The reaction is carried out in the presence of water and hydrogen halide and the concentration of the hydrogen halide in water is greater than 37 wt. %.

Method for producing L-ascorbic acid

The invention relates to a novel heat-stable form of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diph enylacetamide and to a process for the preparation and isolation of this compound in this novel form and to use for the production of medicaments which contain this compound and/or one of its physiologically acceptable salts.

N-methyl-N-[(1S)-1-phenyl-2-(3S)-hydroxypyrrolidin-1-yl)ethyl]-2

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Reinheim, Germany

Klaus Beschmann