Novo Nordisk A/s

Novo Nordisk Healthcare Ag

Klaus Bendix

Mads Schenstroem Stefansen

Soeren Kjellerup Hansen

Matias Melander

Jim Radmer

Christian Hoejris Nielsen

Jonas Hjortlund

Henrik Ljunggreen

Lars Eilertsen

Bastian Gaardsvig Kjeldsen

Nicolai Michael Jensen

Soeren Dyring Jensen

Daniel Patrick Godskesen True

Dan Noertoft Soerensen

Thomas Lindblad

Nick Smartt

Michael Bech Reisenhus

Martin Rasmussen

Christian Højris Nielsen

Mads Schenstrøm Stefansen

Dan Nørtoft SØRENSEN

Søren Kjellerup Hansen

Mads SCHENSTRØM Stefansen

Josefine Carlsson

Søren Dysing Jensen

The present invention provides a drug delivery device () comprising: a drug reservoir () comprising a reservoir body () extending along a reference axis and an elastomeric stopper () arranged in the reservoir body (), the elastomeric stopper () comprising a stopper body () extending between a front stopper end () and a rear stopper end () and having a plurality of axially spaced apart circumferential ribs () for sealing interaction with an interior wall () of the reservoir body (), and a plunger rod structure () for displacing the elastomeric stopper () relative to the interior wall (), the plunger rod structure () extending along the reference axis and comprising a distal end face () adapted to interface with the rear stopper end (). The distal end face () comprises a first force transferring portion () and a second force transferring portion (), the first force transferring portion () axially leading the second force transferring portion () and being adapted to interact with a peripheral portion of the rear stopper end ().

Drug delivery device with plunger rod having nonuniform stopper interface

A drug delivery device includes a dose counting mechanism and an end-of-content or remaining-dose indication. For example, a dose expelling mechanism is coupled to a reciprocating element configured to undergo a predefined motion during each dose expelling action to allow a dose to be expelled. The predefined motion includes displacement in a first axial direction from a first position to a second position followed by displacement in a second axial direction from the second position to the first position, with a counter element being movable in the first axial direction. First and second unidirectional ratchet mechanisms prevent motion in the first axial direction and allow motion in the second axial direction of the reciprocating element relative to the counter element, and vice versa, respectively.

Drug delivery device with dose counting mechanism

The present invention provides a drug delivery device () for sequential administration of substances, comprising a first variable volume reservoir () holding a first substance and comprising a first outlet () and a first displaceable wall (), a second variable volume reservoir () holding a second substance and comprising a second outlet () and a second displaceable wall (), a first wall actuation structure () activatable to move the first displaceable wall () and thereby expel a dose of the first substance through the first outlet (), a second wall actuation structure () activatable to move the second displaceable wall () and thereby expel a dose of the second substance through the second outlet (), and a drive structure () for activating the first wall actuation structure () and the second wall actuation structure (). The drive structure () performs a predetermined movement during one sequential administration of the first substance and the second substance, the predetermined movement comprising a first part movement followed by a second part movement, and is configured to activate the first wall actuation structure () during the first part movement and to activate the second wall actuation structure () during the second part movement.

Mechanism for sequential dose delivery

A method of manufacturing one of a range of autoinjectors having cartridges (&#x2033;) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (&#x2033;), b) providing a cartridge (&#x2033;) of given fill volume, c) providing a rear body assembly () comprising a spring-driven drive ram assembly () configured to drive the piston of a held cartridge (&#x2033;), d) providing a ram spacer member (&#x2033;), the ram spacer member defining a spacing geometry of length dimension (X', X&#x2033;, X&#x2032;&#x2033;, XS&#x2032;, XS&#x2033;, XS&#x2032;&#x2033;, XR&#x2032;, XR&#x2033;, XR&#x2032;&#x2033;) selected according to the fill volume of the cartridge (&#x2033;), and e) assembling a front body assembly (&#x2033;), the cartridge (&#x2033;), the ram spacer member (&#x2033;) and the rear body assembly () so that the ram spacer member (&#x2033;) is arranged axially between the drive ram assembly () of the rear body assembly () and the piston of a held cartridge (&#x2033;).

Method of manufacturing one of a range of autoinjectors

A needle unit () comprising: a needle hub () comprising a needle () and a needle shield (), wherein the needle hub () and the needle shield () are arranged to form a needle unit () where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle () between a shielded position and an exposed position. The needle hub () further comprises a first hub locking element () and a second hub locking element () and the needle shield () further comprises a first shield locking element () and a second shield locking element (), said first hub locking element () and said first shield locking element () engaging each other in the shielded position to establish a first releasable locking mechanism () between the needle hub () and the needle shield (), said second hub locking element () and said second shield locking element () engaging each other in the shielded position to establish a second locking mechanism () between the needle hub () and the needle shield (), both the first and second locking mechanisms () being arranged as shock proof locks, and where the first releasable lock mechanism () is arranged to engage with the lock release element () of the injection device () when the needle unit () is coupled to the injection device, said engagement allowing the first releasable lock mechanism () to be unlocked. The invention further provides an injection device comprising the needle unit and a method of assembling an injection device with the needle unit.

Needle unit with a lockable needle shield and an injection device comprising such a needle unit

The present invention relates to a reservoir unit () for a drug delivery arrangement (), the reservoir unit () comprising: a housing () adapted to accommodate a fluid substance and comprising a displaceable wall (), a fluid transport member () comprising a fluid outlet (), first fluid communication means () for providing fluid communication with an interior of another reservoir, and second fluid communication means () for providing fluid communication with an interior () of the housing (), and coupling means () adapted for connection with mating coupling means associated with the other reservoir. The invention further relates to a drug delivery arrangement () employing the reservoir unit (). The fluid transport member being a needle () fixedly retained by the outlet portion () and having a side hole () in the needle body () just proximally of the outlet portion ().

Arrangement for sequential delivery of fluid volumes

The present invention relates to a medical device () comprising a first container () holding a first medium and defining a general axis, a second container () holding a second medium, and fluid connection means () for establishing fluid connection between the first container () and the second container (), the fluid connection means () being arranged at least partially between the first container () and the second container (). The device further comprises a cover receiving portion () and a cover () removably mounted thereon to shield at least an operable portion of the first container (). The cover () is operatively coupled with the fluid connection means () and configured to cause a relative converging motion between at least one of the first container () and the fluid connection means () and the second container () and the fluid connection means () in response to a dismounting of the cover () from the cover receiving portion ().

Pre-assembled fluid transfer arrangement

Growing community of inventors

Vanloese, Denmark

Klaus Bendix