Ciba-geigy Corporation

Klaus Anton

Peter Van Hoogevest

Ernst Gassmann

Peter E Jordi

Nico Pericles

Peter Datwyler

Lene Frederiksen

The invention relates to a novel, advantageous process for the preparation of liposomes for the inclusion of water-soluble or hydrophilic substances or mixtures of substances, which process provides the surprising advantage, in comparison with known processes, that the proportion of substances or mixtures of substances actually included is increased and which, when used pharmaceutically, provides the advantage of sterile working conditions. In this process, a mixture consisting of at least one phospholipid and customary lipophilic excipients is subjected to a mobile carrier phase consisting of carbon dioxide and a polar organic solvent (modifier) under supercritical pressure and temperature conditions, the compressed mixed phase is reduced to normal pressure and transferred to an aqueous phase comprising a substance having water-soluble or hydrophilic properties for encapsulation in liposomes.

Process for the preparation of a liposome dispersion under elevated

A micro-flow cell for chromatographic, spectrometric or scintillation measurements comprises a capillary tube, preferably made of glass or silica glass, through which flows the medium to be examined, and a holding device for said capillary tube. The holding device is separably composed of at least two parts which can be separated in their longitudinal direction. The capillary tube is fixed in the holding device by suitably formed connectors so as to be stress-free and tension-free to the greatest possible extent.

Micro-flow cell

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Basel, Switzerland

Klaus Anton