Contipro A.s.

Klara Slezingrova

Vladimir Velebny

Radovan Buffa

Kristina Nesporova

Gloria Huerta-Angeles

Romana Sulakova

Jaromir Kulhanek

Josef Chmelar

Lucie Wolfova

Miroslava Nemcova

Daniela Smejkalova

Jaroslav Novotny

Martina Hermannova

Dagmar Cozikova

Jana Sogorkova

Pavel Klein

Antonin Minarik

Martin Bobek

Jan Kucera

Marcela Dusankova

Lucie Vistejnova

Sergej Karel

Eva Prikopova

Jiri Betak

Jolana Scudlova

Ilona Matejkova

Tomas Pitucha

The invention relates to a self-supporting, biodegradable film comprising a C-C-acylated derivative of hyaluronic acid according to the general formula (I), where R is Hor Na, and where Ris H or &#x2014;C(&#x2550;O)CH, where x is an integer within the range from 9 to 21 and y is an integer within the range from 11 to 43 and CHis a linear or branched, saturated or unsaturated C-Cchain, wherein in at least one repeating unit one or more of Ris &#x2014;C(&#x2550;O)CHand where n is within the range from 12 to 4000; a method of preparation thereof and use thereof. 

Self-supporting, biodegradable film based on hydrophobized hyaluronic acid, method of preparation and use thereof

The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications. 

[object Object]

Growing community of inventors

Nekor, Czechia

Klara Slezingrova